Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery

We propose a terahertz (far-infrared) circular dichroism-based life-detection technology that may provide a universal and unequivocal spectroscopic signature of living systems regardless of their genesis. We argue that, irrespective of the specifics of their chemistry, all life forms will employ well-structured, chiral, stereochemically pure macromolecules (>500 atoms) as the catalysts with which they perform their metabolic and replicative functions. We also argue that nearly all such macromolecules will absorb strongly at terahertz frequencies and exhibit significant circular dichroism, and that this circular dichroism unambiguously distinguishes biological from abiological materials. Lastly, we describe several approaches to the fabrication of a terahertz circular dichroism spectrometer and provide preliminary experimental indications of their feasibility. Because terahertz circular dichroism signals arise from the molecular machinery necessary to carry out life's metabolic and genetic processes, this life-detection method differs fundamentally from more well-established approaches based on the detection of isotopic fractionation, "signature" carbon compounds, disequilibria, or other by-products of metabolism. Moreover, terahertz circular dichroism spectroscopy detects this machinery in a manner that makes few, if any, assumptions as to its chemical nature or the processes that it performs.     

The reactions of nitrogen heterocycles with acrolein: scope and prebiotic significance

It has been suggested that life began with a self-replicating RNA molecule. However, after much research into the prebiotic synthesis of RNA, the difficulties encountered have lead some to hypothesize that RNA was preceded by a simpler molecule, one more easily synthesized prebiotically. Many of the proposed alternative molecules are based on acrolein, since it reacts readily with nucleophiles, such as the nucleobases, via Michael addition and is readily synthesized from formaldehyde and acetaldehyde. Reports regarding the reactions of nucleobases with concentrated acrolein solutions suggest that this is a plausible reaction mechanism, though there are also reports that the "incorrect" isomers are obtained. The scope and kinetics of the reaction of acrolein with various nitrogen heterocycles are reported here. Reactions of pyrimidines often give N(1) adducts as the major products. Reactions of purines often give N(9) adducts in good yield. The reactions are rapid under neutral to slightly alkaline conditions, and proceed at low temperatures and dilutions. The implications of these findings for the origin of life are discussed.     

The Geology of Mercury: The View Prior to the MESSENGER Mission

Mariner 10 and Earth-based observations have revealed Mercury, the innermost of the terrestrial planetary bodies, to be an exciting laboratory for the study of Solar System geological processes. Mercury is characterized by a lunar-like surface, a global magnetic field, and an interior dominated by an iron core having a radius at least three-quarters of the radius of the planet. The 45% of the surface imaged by Mariner 10 reveals some distinctive differences from the Moon, however, with major contractional fault scarps and huge expanses of moderate-albedo Cayley-like smooth plains of uncertain origin. Our current image coverage of Mercury is comparable to that of telescopic photographs of the Earth’s Moon prior to the launch of Sputnik in 1957. We have no photographic images of one-half of the surface, the resolution of the images we do have is generally poor (∼1 km), and as with many lunar telescopic photographs, much of the available surface of Mercury is distorted by foreshortening due to viewing geometry, or poorly suited for geological analysis and impact-crater counting for age determinations because of high-Sun illumination conditions. Currently available topographic information is also very limited. Nonetheless, Mercury is a geological laboratory that represents (1) a planet where the presence of a huge iron core may be due to impact stripping of the crust and upper mantle, or alternatively, where formation of a huge core may have resulted in a residual mantle and crust of potentially unusual composition and structure; (2) a planet with an internal chemical and mechanical structure that provides new insights into planetary thermal history and the relative roles of conduction and convection in planetary heat loss; (3) a one-tectonic-plate planet where constraints on major interior processes can be deduced from the geology of the global tectonic system; (4) a planet where volcanic resurfacing may not have played a significant role in planetary history and internally generated volcanic resurfacing may have ceased at ∼3.8 Ga; (5) a planet where impact craters can be used to disentangle the fundamental roles of gravity and mean impactor velocity in determining impact crater morphology and morphometry; (6) an environment where global impact crater counts can test fundamental concepts of the distribution of impactor populations in space and time; (7) an extreme environment in which highly radar-reflective polar deposits, much more extensive than those on the Moon, can be better understood; (8) an extreme environment in which the basic processes of space weathering can be further deduced; and (9) a potential end-member in terrestrial planetary body geological evolution in which the relationships of internal and surface evolution can be clearly assessed from both a tectonic and volcanic point of view. In the half-century since the launch of Sputnik, more than 30 spacecraft have been sent to the Moon, yet only now is a second spacecraft en route to Mercury. The MESSENGER mission will address key questions about the geologic evolution of Mercury; the depth and breadth of the MESSENGER data will permit the confident reconstruction of the geological history and thermal evolution of Mercury using new imaging, topography, chemistry, mineralogy, gravity, magnetic, and environmental data.     

Auroral Radio Emissions, 1. Hisses, Roars, and Bursts

The Earth's auroral electrons produce copious non-thermal radio emissions of various types, including auroral kilometric radiation (AKR), whistler mode auroral hiss, mode conversion radiation such as auroral roar and MF-burst, and possibly HF/VHF emissions. In some cases, mechanisms have been identified and quantitatively described, whereby the energy of the auroral electrons is converted into electromagnetic radiation. In many other cases, the radiation mechanism, or the relative significance of several possible mechanisms, remains uncertain. This review covers fairly comprehensively experimental and theoretical research on types of auroral radiation other than AKR, concentrating on emissions with frequency higher than about 1kHz and treating only emissions which are unique to the auroral zone. The review covers both ground-based and in-situ observations. It covers a wide range of theoretical approaches, emphasizing those which at present appear most important for producing non-AKR auroral radiations.     

High accuracy satellite drag model (HASDM)

The dominant error source in force models used to predict low-perigee satellite trajectories is atmospheric drag. Errors in operational thermospheric density models cause significant errors in predicted satellite positions, since these models do not account for dynamic changes in atmospheric drag for orbit predictions. The Air Force Space Battlelab’s High Accuracy Satellite Drag Model (HASDM) estimates and predicts (out three days) a dynamically varying global density field. HASDM includes the Dynamic Calibration Atmosphere (DCA) algorithm that solves for the phases and amplitudes of the diurnal and semidiurnal variations of thermospheric density near real-time from the observed drag effects on a set of Low Earth Orbit (LEO) calibration satellites. The density correction is expressed as a function of latitude, local solar time and altitude. In HASDM, a time series prediction filter relates the extreme ultraviolet (EUV) energy index E_10.7 and the geomagnetic storm index a_p, to the DCA density correction parameters. The E_10.7 index is generated by the SOLAR2000 model, the first full spectrum model of solar irradiance. The estimated and predicted density fields will be used operationally to significantly improve the accuracy of predicted trajectories for all low-perigee satellites.     

Recent studies of the optical counterpart of GX 1+4

The galactic X-ray source GX 1+4 has been undergoing remarkable changes since early 1991. The X-ray pulsar has shown fast spin down accompanied by an increase in the hard X-ray intensity. We have obtained 1.6Å resolution spectra of the optical counterpart extending the known spectrum to 8500Å. The Ca II (8498Å) line seen for the first time from this source is indicative of a nova burst scenario. Other lines detected for the first time are detailed and the significance of these features is discussed.     

CONSERVATIVE FRONT TRACKING IN HIGHER SPACE DIMENSIONS

INTRODUCTIONWe propose and demonstrate a tracking fi-nite difference algorithm which is( a) fully con-servative and ( b) improves local truncation errorby one order( from O( 1 ) to O( Δx) near trackeddiscontinuities.Discontinuities in the solutions of systems ofnonlinear hyperbolic conservation laws are widelyrecognized as a primary difficulty for numericalsimulation.Surprisingly,the nonlinearities actu-ally help,as they cause information,which flowsalong solution characteristics,to flow…     

Reflex contributions to the assessment of the vertical

On the ground the vertical directions "up" and "down" have significance in relation to the strategy for avoiding collision of the skull with the planet. Voluntary acts to this end may be based on the experienced result of reflexly generated motor commands. Relevant receptors lie in the otolith organs of the labyrinth, but the head is seldom steady in waking life. A revised scheme of labyrinth reflexes on the limbs--"downhill limbs extend"--replaces the classical scheme of Magnus. Interactions with neck reflexes according to this scheme serve to stabilize the trunk. In an orbiting spacecraft the pattern of afferent signals from the labyrinth differs from that on the ground, and predictions based on the new scheme are to be tested in the project "Operation Push-Pull" proposed for ESRO's Spacelab. Other activities of the Council of Europe's Working Party on Aerospace Physiology and Medicine are briefly described.     

Communicating bioastronautics research to students, families and the nation

The National Space Biomedical Research Institute (NSBRI) is supporting the National Aeronautics and Space Administration's (NASA) education mission through a comprehensive Education and Public Outreach Program (EPOP) that communicates the excitement and significance of space biology to schools, families, and lay audiences. The EPOP is comprised of eight academic institutions: Baylor College of Medicine, Massachusetts Institute of Technology, Morehouse School of Medicine, Mount Sinai School of Medicine, Texas A&M University, University of Texas Medical Branch Galveston, Rice University, and the University of Washington. This paper describes the programs and products created by the EPOP to promote space life science education in schools and among the general public. To date, these activities have reached thousands of teachers and students around the US and have been rated very highly.